TLR4 and acute kidney injury: Combined with the reverse effect of TAK242 and PDTC blockade on renal structure, function and proinflammatory mediators, our results indicate that the MyD88-dependent TLR4/NF-κB signaling pathway is involved in regulation of burn-induced inflammation and related injury in kidneys and might be a pivotal target to prevent or treat burn-induced early AKI.