The median (IQR) serum HIF-1α levels of overall preeclampsia and late-onset preeclampsia were 1315.2 (645.9, 5128.7), and 1715.5 (852, 5134) pg/ml, respectively, which were significantly higher than that of normal pregnant women (699.5 (426.8, 1107.1) pg/ml) (p < 0.001, and < 0.001, respectively). Here, HIF1A is linked to preeclampsia.