Early screening of preeclampsia by using a combination of serum HIF-1α levels and uterine artery Doppler during the first trimester (11–13+6 weeks of gestation) allows the timing for using early low-dose aspirin prophylaxis in order to prevent preeclampsia, which may be more effective if started prior to 16 weeks of gestation7. The gene discussed is HIF1A; the disease is preeclampsia.