RPS6KB1 and non-small cell lung carcinoma: Western blot analysis also revealed that ETD was able to downregulate the expression levels of p-mTOR (Ser2448) and p-p70S6K (Thr389), members of a downstream signaling axis of Akt that regulates cell motility and invasion21,22, in A549 and H460 cells, suggesting that Akt/mTOR/p70S6K signaling is a possible target by which ETD inhibits non-small-cell lung cancer cell migration and invasion.