PLXNB2 and cancer: Recently, plexin-B2 (PLXNB2), a transmembrane receptor belonging to the large family of plexin proteins, was identified as a functional ANG receptor that is both necessary and sufficient for the physiological and pathological functions of ANG in multiple cell types, including endothelial, cancer, neuronal, normal hematopoietic and leukemic stem and progenitor cells, as well as intestinal epithelial cells63,64.