CTRL and Alzheimer disease: Likewise, cortical neurons produced from the differentiation of iPSCs from three unrelated AD cases (AD1, AD2, and LG) presented increased H3K9ac levels that correlated with the accumulation of G4 structures, when compared to control iPSC-derived neurons from two unrelated non-demented elderly cases (Ctrl1 and Ctrl2) (Fig. 2c and Supplementary Fig. 5; see Experimental procedures for description of the iPSC lines).