Mutations most commonly detected in CH include the epigenetic regulators DNMT3A, TET2, and ASXL1. From the results of transplantation experiments using Tet2-deficient or Dnmt3a-deficient mice, the increased self-renewal of HSCs could explain why loss-of-function mutations of DNMT3A and TET2 are frequently detected in CH30–33. Here, DNMT3A is linked to cyclic hematopoiesis.