Analyses of peripheral blood cells showed mild leukocytopenia and mild anemia, which are prominent when compared with age-matched control mice, as well as moderate thrombocytosis in aged Vav-Cre ASXL1-MT KI mice (hereinafter, all experiments were performed with 20–24-month-old for aged mice) (Fig. 2a). The gene discussed is ASXL1; the disease is thrombocytosis disease.