Klotho, a fibroblast growth factor- 23 (FGF-23) co-receptor, has a well-recognized function in the aging process and may represent a link between aging and kidney disease [10]; Klotho plays a key role in the regulation of aging, particularly at the cardiovascular level, by inhibiting local phosphate uptake into vascular smooth muscle cells (VSMCs), and their differentiation in osteoblast-like cells and preservation of endothelial function [11, 12]. The gene discussed is FGF23; the disease is kidney disorder.