ZDHHC5 and schizophrenia: Interestingly, a de novo mutation in Zdhhc5 has been reported in a patient with schizophrenia that introduces a premature stop codon at residue 648 (E648), resulting in the loss of the last 68 amino acids of Zdhhc5 (Fromer et al., 2014), including the PDZ-binding motif (Li et al., 2010; Brigidi et al., 2015).