Interestingly, Tiam1 depletion, although largely suppressing tumour formation (Malliri et al., 2002, 2006), promotes malignant progression (Malliri et al., 2002, 2006), indicating a dual oncogene/tumour suppressor role for Tiam1 (Maltas et al., 2020). The gene discussed is TIAM1; the disease is neoplasm.