The reduced incidence and size of tumours in Gpr35ΔMΦ mice was not linked to protection from DSS-induced colitis, as weight loss during short-term (ie, 7 days) DSS, nor during the three cycles of AOM/DSS was indifferent between Gpr35+/+ and Gpr35–/–, and Gpr35fl/fl and Gpr35ΔMΦ mice (online supplemental figure 1A–C). Here, GPR35 is linked to neoplasm.