Angiotensin peptides bind to Agtr1 and Agtr2 receptors on vascular cells to help regulate vasoconstriction, and on the adrenal to stimulate secretion of aldosterone, leading to salt and water retention, which may be related to comorbidities of hypertension and obesity-related kidney damage (Fyhrquist and Saijonmaa, 2008). The gene discussed is AGTR1; the disease is obesity due to melanocortin 4 receptor deficiency.