AGT and obesity due to melanocortin 4 receptor deficiency: Hypertension, obesity, and diabetes are COVID-19 comorbidities (Richardson et al., 2020); they relate to the role of the RAAS in salt and water balance, vessel function, and inflammation; and they lie downstream of Ang II (Cabandugama et al., 2017; Fyhrquist and Saijonmaa, 2008).