SLC22A8 and gout: Three well-characterized pathophysiological examples are the roles of OAT1, OAT3, URAT1, and ABCG2 in gout (10), the role of OAT1 and OAT3 in the accumulation of uremic toxins associated with chronic kidney disease (CKD) (11, 12), and the SLC22 family in acute kidney injury (13).