LOXL4 and head and neck squamous cell carcinoma: LOXL4 was first proposed as a selective molecular marker for HNSCC by Gorogh, et al.13in a 2007 paper that demonstrated overexpression of LOXL4 mRNA transcript in 74% of invasive HNSCC tumors and 90% of both primary and metastatic HNSCC cell lines.