LOXL4 and neoplasm: Among 29 patients that were treated primarily with total laryngectomy, enlarging tumors had a tendency to lose LOXL4 expression (mean tumor diameter 4.1 ± 0.49 [LOXL4 negative] vs. 3.4 ± 0.38 [LOXL4 positive]) but this trend did not reach statistical significance (p = 0.456) (Fig. 2).