CPT2 and cardiac hypertrophy: To determine if supplementation with octanoate would alleviate cardiac hypertrophy in CPT2 deficiency (Fig. 1A) by bypassing the carnitine-mediated transport shuttle for mitochondrial oxidation, we fed control and myocardial CPT2-deficient mice (Cpt2M−/−), a diet supplemented with trioctanoin, a triacylglycerol containing three 8-carbon-long acyl chains, as 20% wet weight in the regular diet.