Among 40 SNPs which previously displayed genome-wide significant associations with clinical AD diagnosis in large case–control studies through the IGAP consortium [36, 37], nominal associations (p < 0.05) were identified for three variants: the AD risk allele BIN1 rs6733839-T was associated with worse memory trajectory (p = 0.01, β = -0.11); the AD protective allele SORL1 rs11218343-C was associated with better memory trajectory (p = 0.04, β = 0.09); and the AD protective allele MEF2C rs190982-G was associated with worse memory trajectory (p = 0.03, β = -0.09). This evidence concerns the gene BIN1 and Alzheimer disease.