In addition to the cell type specificity, the tau isoform from the diseased donor, be it 3R or 4R tau, were recapitulated in the recipient mouse: brain extracts from AD cases seeded 3R and 4R tau, while PSP and CBD brain extracts seeded 4R tau, and PiD seeded 3R tau [78, 79]. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.