Indeed, astrocytic tau changes can be a cardinal neuropathologic (if not pathognomonic) lesion in primary tauopathies, including tufted astrocytes in PSP, astrocytic plaques in CBD, globular astroglial inclusions in GGT, and ramified astrocytes in PiD [41, 42, 59]. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.