It would be continued debate on how to choose the first line treatment for AML with these mutations: hypomethylating agents with IDH1/2 inhibitors vs venetoclax-based combination; how to sequence the treatment options: venetoclax-based combinations first followed by IDH1/2 inhibitors at disease relapse/ progression or the other way around; or use three drugs combination with HMA + venetoclax + IDH1/2 inhibitor to get deeper remission. Here, IDH1 is linked to acute myeloid leukemia.