Sorafenib maintenance was recently demonstrated to reduce the risk of relapse and death after allo-SCT for FLT3-ITD-positive AML in the randomized clinical trial, providing the first solid evidence for the success of maintenance post allo-SCT in AML patients [129], and Phase III MORPHO Trial is under way to evaluate gilteritinib as maintenance after allo-SCT in patients with FLT3 mutation-positive AML (NCT02997202). This evidence concerns the gene FLT3 and acute myeloid leukemia.