IDH1 and acute myeloid leukemia: Future clinical research will focus on deepening the responses provided by HMA + venetoclax with additional targeted agents, like ivosidenib in IDH1 mutated AML (to be discussed in next section), FLT3 inhibitors, and novel pathways inhibitors to eventually cure a greater fraction of newly diagnosed AML, and to explore new strategies to deal with relapses after venetoclax-based therapies.