IDH2 and acute myeloid leukemia: It is reasonable to expect that combination of the IDH2 inhibitor enasidenib with venetoclax and azacitidine might also provide better outcomes than enasidenib alone or enasidenib with azacitidine, since enasidenib plus venetoclax demonstrated superior anti-leukemic activity against IDH2 mutated AML in patient-derived xenograft models [48].