As for the IDH2 inhibitor of enasidenib, the phase II portion of an open-label, randomized phase I/II study of enasidenib (E) + AZA (“E + A”) vs AZA monotherapy (“A”) in patients with mutated IDH2 (mIDH2) ND AML (NCT02677922) was recently reported [44]. This evidence concerns the gene IDH2 and acute myeloid leukemia.