SPRY4 and metastatic malignant neoplasm in the lymph nodes: Among 32 patients with high expression of SPRY4-IT1 harboring lymph-node metastasis, 19 patients (59.4%) had cervical and superior mediastinal lymph-node metastasis and 13 patients (40.6%) only had others’ site lymph-node metastasis that didn’t include cervical and superior mediastinum.