Xie et al. reported that the relative expression level of SPRY4-IT1 was associated with T stage, lymph node metastasis, and advanced pathological stage of ESCC patients, SPRY4-IT1 high expression was correlated with lower overall survival rates and could be an independent prognostic factor in patients with ESCC [13]. This evidence concerns the gene HAUS3 and esophageal squamous cell carcinoma.