SPRY4 and neoplasm: As shown in Table 1, the high expression of SPRY4-IT1 was correlated with tumor differentiation (P = 0.029), T classification (P = 0.013), lymph node metastasis(P = 0.022) and pathological stage (P = 0.001) but not correlated with patient’s age, gender, smoking status, alcohol consumption, tumor location, and lymph-node recurrence(P > 0.05).