PLXNB2, a member of the B class of plexins, is a transmembrane receptor involved in cell migration and axonal guidance [22], regulates the cellular immune response [23, 24], functions as the receptor for angiogenin to regulate angiogenesis in malignant tumours, including AML [25], and exerts important effects on the activation of RHOA [22]. Here, PLXNB2 is linked to cancer.