Our previous report demonstrated that irradiated TSA breast cancer cells release tumor-derived exosomes (RT-TEX) containing a DNA cargo that stimulates IFN-I production in recipient dendritic cells (DCs) via the cGAS/STING pathway, whereas exosomes secreted by untreated cells (UT-TEX) contain DNA that is unable to stimulate IFN-I [4]. The gene discussed is CGAS; the disease is breast carcinoma.