At surgery tumors from NICOLE cohort showed significantly higher level of CD8 T-cells infiltration (p =  < 0.035) and significant higher Immunoscore (densities of CD3 + and CD8 + T-cells in tumor and invasive margin regions) (p = 0.028), compared to a control cohort of 22 colon cancer patients undergoing surgery without treatment. This evidence concerns the gene CD8A and malignant colon neoplasm.