As a critical factor involved in ribosome assembling and mRNA catabolic process, RPS4X has been reported by Lebel et al. that its depletion confers cisplatin resistance but reduces the proliferative growth rate by interacting with Y-box binding protein 1 (YB-1) in breast and ovarian cancer cell lines [18, 20]. The gene discussed is YBX1; the disease is ovarian cancer.