Anti-tumour immunotherapy with monoclonal antibodies blocking the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) pathways are gaining momentum, where immune checkpoint inhibitors directed against these targets either alone or in combination have shown efficacy in HCC. Here, CTLA4 is linked to neoplasm.