In a study with combination of Bacillus Calmette-Guerin (BCG) injection and tumor vaccine, 18% of the patients remained alive and disease-free and it has been reported that bacterial vaccine caused increased level of immunoregulatory cytokines such as TNF-α, IFN-γ, and IL1-β that might be involved in inducing tumor regression [66]. Here, TNF is linked to neoplasm.