Beside these, we do not see any significant correlation between expression levels of CD274 and PDCD1LG2 genes, that encodes PD-L1 and PD-L2 respectively, with the expression levels of PDCD1 and IFNG, and the percentage of CD8 T cells in osteosarcoma tumors (Figure 6). This evidence concerns the gene CD274 and osteosarcoma.