The first automated approach was dedicated to control hypoglycemia: the Low Glucose Suspend system (LGS) interrupts insulin infusion for a maximum of 2 h when a predetermined low glucose level is reached: this approach can reduce severe hypoglycemia, even if compared to SAP without LGS [89], especially in T1D at high risk of hypoglycemia or with reduced hypoglycemia awareness [90]. This evidence concerns the gene INS and type 1 diabetes mellitus.