In a swine model with early-stage metabolic syndrome and hyperglycemia, despite both adenosine-induced increase in coronary blood flow in vivo and the adenosine analogue-mediated relaxation in isolated coronary arterioles did not differ from control swine [8], there was a shift from the A2AR-mediated coronary relaxation to enhanced A2BR-mediated coronary relaxation in swine with early-stage metabolic syndrome [8] (Table 2). Here, ADORA2A is linked to metabolic syndrome.