Further, the multicenter Idylla MSI test study of CRC reported ACVR2A to be the most often mutated biomarker (94.0%) and SEC31A to be the least mutated marker (60.9%) [11], and our frequencies are in line with a sequencing study demonstrating ACVR2A mutations in 92% and SEC31A mutations in 54% of one hundred MSI CRC cases [27]. The gene discussed is SEC31A; the disease is colorectal carcinoma.