MSH6 and colorectal carcinoma: [6] The sensitivity to detect MSI in dMMR CRC tumors using PCR-based microsatellite tests has been reported to be 89% for MLH1/MSH2 deficient but only 77% for MSH6 deficient cases [9], and in EC, the sensitivity has been estimated to range from 41 to 100% and the specificity from 69 to 89% [10].