We extended the receptor-ligand analysis to better understand all potential ligand-receptor changes between subsets of patients; this confirmed the differential activation of the CCL2-CCR2 ligand-receptor pair in the Myeloid-enriched IPF subset and revealed additional major changes in active receptor-ligand interactions between Subsets 1 and 2. Here, CCL2 is linked to idiopathic pulmonary fibrosis.