Notably, the eyes of nanophthalmic individuals with biallelic mutations in PRSS56 or MFRP were found to be significantly smaller as compared to those carrying dominant mutations in TMEM98 or MYRF. Interestingly, common PRSS56 and MFRP variants have also been found to be associated with myopia, a condition phenotypically opposite to nanophthalmos that is characterized by excessive ocular growth [11,12]. This evidence concerns the gene PRSS56 and microphthalmia.