In accordance, several PC were also detected in significantly lower levels in CHM patients, such as PC(16:0/22:6) (FC 0.88, P < 0.05) and PC(18:1/22:6) (FC 0.87, P < 0.05) (data not shown), implying phospholipid deregulation caused by REP1 deficiency. Here, CHM is linked to choroideremia.