As shown in Figure 6D, AMACR knockdown did not affect CDX2 expression, consistent with it being downstream of CDX2.To validate the relationship between CDX2 and AMACR in human CRCs, we next evaluated The Cancer Genome Atlas (TCGA) for CDX2 and AMACR in colon and rectal adenocarcinomas (COADREAD). The gene discussed is CDX2; the disease is rectum adenocarcinoma.