LIN28B and colorectal carcinoma: As shown in Figure 1G, ALP activity in Caco-2 cells with LIN28B knockdown was significantly lower compared with that in Caco-2 control cells at day 3 after confluence, whereas there was no significant difference between the 2 groups in subconfluent Caco-2 cells (Supplemental Figure 1C), suggesting that LIN28B may accelerate CRC tumor differentiation through ALP activation.