Although brentuximab vedotin (BV) with cyclophosphamide, doxorubicin, and prednisone has shown clear benefits over CHOP in patients with untreated CD30-positive PTCL, subgroup analysis revealed no advantages of adding BV in patients with AITL and PTCL-NOS17. This evidence concerns the gene TNFRSF8 and angioimmunoblastic T-cell lymphoma.