To target the highly proliferative GBM cells, we constructed retroviral vectors that efficiently targeted dividing cells to overexpress Neurog2 (CAG::Neurog2-IRES-eGFP), NeuroD1 (CAG::NeuroD1-IRES-eGFP), or Ascl1 (CAG::Ascl1-IRES-eGFP) in GBM cells. This evidence concerns the gene NEUROD1 and glioblastoma.