NEUROD4 and glioblastoma: For example, Masserdotti et al.35 reported that after ectopic expression in astrocytes, Neurog2 activated neuronal genes involved in glutamatergic neuron maturation such as INSM1 and NeuroD4, which were also found exclusively upregulated by Neurog2, but not Ascl1, during our human GBM cell conversion.