As the proliferative effect of conditioned media was also correlated to CIRP, CAV1 and CAVIN1 expression in MCTP‐treated rPAECs, it is intriguing to identify these proliferation factors and investigate the underlying mechanisms, that is, how CIRP regulates their expression, which may facilitate the development of new targets for the treatment of PAH. Here, CIRBP is linked to pulmonary arterial hypertension.