In patients with nephrotic syndrome, IgA nephropathy, primary mesangial proliferative glomerulonephritis, and membranous nephropathy, including minimally symptomatic patients, GRP78 and an inducible endoplasmic reticulum (ER) chaperone molecule oxygen-regulated protein 150 (ORP150) immunohistochemical expressions were increased compared to controls. The gene discussed is HSPA5; the disease is IgA glomerulonephritis.