CIBERSORT analysis of the proportion of TICs suggested that CD8+ T cell and T-cell regulation were negatively associated with SERPINE1 expression, showing that SERPINE1 may inhibit the immune-dominant status of the tumor microenvironment (TME) in GC.<h4>Conclusions</h4>Our analysis shows that SERPINE1 is closely correlated with the tumorigenesis and progression of GC. This evidence concerns the gene CD8A and gastric cancer.