Previous studies have shown lupus‐prone mouse macrophages were reported to display impaired lysosomal maturation that can lead to accumulation of nuclear antigens to the cell surface that can potentially activate autoreactive lymphocytes42; however, this study found there exist NKT like cells undergoing pyroptosis in LN kidney as IRF7/STAT1/CASP4 expressed higher in the NKT like cell cluster of LN compared with that of donor control. Here, CASP4 is linked to systemic lupus erythematosus.