Meanwhile, some membranous nephropathy (MN) high expressed genes such as HLA‐DRB5, HLA‐DQA2, IFNG, CCL2 and NR4A2, which involve in highest enrichment pathway, display the cellular‐specific expression style, whereas monocyte marker of lupus nephritis (LN) named TNFSF13B was also found and interferon alpha/beta signalling pathway was enriched in B and NKT of LN comparing with donor. The gene discussed is HLA-DRB5; the disease is lupus nephritis.