In lgAN and CIN samples, the higher expression of TPSB2 and TPSAB1 in mast cells contributes to profibrogenesis 23, 24, 25; thus, there are more interstitial fibrosis in IgAN and CIN patients (Extended Figure 1 and Figure 1D). The gene discussed is TPSB2; the disease is cervical squamous intraepithelial neoplasia.