One clinical study showed urine and serum levels of CCL5 were elevated in active LN as compared with disease remission,43 and our data showed CCL5 expressed in NKT like cell cluster can interact with the receptor SDC4 expressed in PT, mesangial and NKT like cell cluster, whereas CCL5 interact with the receptor CCR1, which is expressed in macrophage and neutrophil. Here, SDC4 is linked to lobular neoplasia.