Third, increasing pulmonary congestion on the CXR score is related to worsening HF as assessed by other clinical measures such as age, potassium, urea, NT-proBNP, haemoglobin and albumin, and is associated with increasing all-cause mortality, but not related to overall prognosis when these other variables are taken into account. The gene discussed is NPPB; the disease is hydrops fetalis.