CALB2 and Huntington disease: In a study by Gonzalo and Plesec [19], all patients without HD had calretinin positive nerve fibres in lamina propria or muscularis mucosa and all patients with HD showed no calretinin staining of nerve fibres in the same regions. Guinard-Samuel et al. [20] also noticed 12 cases as suspicious for HD And these suspicious cases were accurately diagnosed by calretinin immunohistochemistry.