METTL3 and familial pancreatic carcinoma: In pancreatic cancer, cigarette smoke condensate (CSC) is able to induce the hypomethylation of METTL3 through attenuating the bindings of DNMT1 and DNMT3a to the METTL3 promoter, which leads to the up-regulation of METTL3 and the following increased m6A levels of pri-miR-25 (Figure 2B) 64.