GLS and colitis: Therefore, we determined the effects of PPARγ agonists on mice with colitis or asthma and further confirmed the critical effect and mechanism of GLS1-mediated metabolism in PPARγ-mediated function, as GLS1 overexpression rescued the in vivo inhibitory effects of ROSI and PIO on 2-HG/H3K4me3 and GSH/ROS signals, Th17 responses and disease features.