Castelo-Branco et.al identified novel DNA methylation markers, of which cg12374721 (PRAC2), cg18081940 (TDRD10) and cg04475027 (TMEM132C) could be useful for breast cancer classification and prognosis, particularly in estrogen-receptor (ER)-positive samples 5. The gene discussed is ESR1; the disease is breast carcinoma.