In agreement with the finding that overexpression of hepatic miR-378 had no effect on CYP7A1 expression levels, the serum 7α-hydroxy-4-cholesten-3-one (C4) levels, which normally reflect the activity of CYP7A1 31, were not altered after Ad-378 infection (Figure S2D). The gene discussed is CYP7A1; the disease is infection.