MAFG and coinfection: To test whether MAFG is the primary target gene responsible for the effect of miR-378 on BA and cholesterol metabolism, we restored the protein levels of MAFG back to a normal range in the liver of Ad-378-infected mice by co-infection with Ad-MAFG, which failed to be repressed by miR-378 due to the absence of 3'UTR (Figure 4A).