Although PDT increased the in vitro cytotoxicity of IgBD-TRAIL and TRAIL to similar degrees (Figure 4E, Figure S7B), the combination of long-acting IgBD-TRAIL and PDT induced greater apoptosis than did by TRAIL with short serum half-life combined with PDT in tumor grafts (Figure 5B, Figure 7B). The gene discussed is TNFSF10; the disease is neoplasm.