In fact, PDT significantly increased death receptor DR4 and DR5 for TRAIL, Fas for Fas L and TNFRSF1A for TNFα (Figure 4C and Table S3), providing the molecular basis for synergy between PDT and TRAIL, Fas L, and TNFα in the killing of CRC cells. This evidence concerns the gene TNFRSF1A and colorectal carcinoma.