Although the in vitro cytotoxicity of TRAIL was similar to that of IgBD-TRAIL in COLO 205 cells (Figure 1C), intravenous injection of a single low-dose (3 mg/kg) IgBD-TRAIL, but not high-dose (10 mg/kg) TRAIL, eradicated large (~300 mm3) tumor grafts of COLO 205 cells within 1 week. The gene discussed is TNFSF10; the disease is neoplasm.