TNFSF10 and colorectal carcinoma: The IC50s of IgBD-TRAIL and TRAIL in LS174T cells treated with PDT were over 10-40 times (approximately 1-3 nM vs 30-40 nM) lower than that in LS174T cells without PDT treatment (Figure 4E), demonstrating the synergy between PDT and TRAIL proteins in killing CRC cells.