TNFSF10 and colorectal carcinoma: Nevertheless, the IC50s of TRAIL in LS174T and LS180 (30-40 nM), HT29 and LOVO (200-300 nM), and other CRC cells (> 500 nM) were much higher than those of TRAIL in COLO 205 and HCT116 cells (0.2-0.5 nM).