TFPI and blood coagulation disease: A recent study showed that anticoagulants, including recombinant human activated protein C (rhAPC), antithrombin (AT), tissue factor pathway inhibitor (TFPI), unfractionated heparin (UFH), low molecular weight heparin (LMWH), and serine protease inhibitors resulted in no survival benefits in the overall sepsis population and even in the population with sepsis-induced coagulopathy 5.