Our recent study identified that the sFgl2 ameliorates sepsis by increasing n-3 docosapentaenoic acid-derived resolvin D5 (RvD5n-3 DPA, also named RvDp5) 10, a specialized pro-resolving lipid mediator (SPM) derived from n-3 docosapentaenoic acid (DPA) by 15-lipoxygenase (15-LOX or ALOX15) catalyzation 11-13. This evidence concerns the gene ALOX15 and Sepsis.