In alcohol-induced HCC, IL-1α and IL-1β are significantly negatively correlated with SPTBN1 (IL-1α vs SPTBN1: correlation coefficient = -0.67 and p-value = 0.001; IL-1β vs SPTBN1: correlation coefficient = -0.49 and p-value = 0.001) but the negative correlation of IL-6 with SPTBN1 did not reach statistical significance (correlation coefficient = -0.39 and p-value = 0.077) (Figure 1C-III). The gene discussed is IL1B; the disease is hepatocellular carcinoma.