Of 212 HCC samples, 36 (17%) had all three cytokines (IL-1β, IL-6, and IL-1α) above the median level and SPTBN1 below the median level, while 45-54% had two of the three cytokines above the median level and SPTBN1 below the median level. The gene discussed is IL1B; the disease is hepatocellular carcinoma.