Further analysis indicated that, compared to livers from DDC treated WT and combination of DDC with NF-κB inhibitor treated Sptbn1+/- mice, IL-1α, IL-1β and IL-6 mRNA levels were increased in tumor burden livers from DDC treated Sptbn1+/- mice (n = 3) (Figure 7C), which clearly demonstrate that the increased pro-inflammatory cytokines upon suppression of SPTBN1 were p65-dependent. This evidence concerns the gene SPTBN1 and neoplasm.