Correlation analysis showed a significant negative correlation between SPTBN1 and IL-1α (correlation coefficient = -0.245, p-value = 2.37E-4); and between SPTBN1 and IL-1β (correlation coefficient = -0.355, p-value = 6.56E-08) in the HBV-induced HCC study (Figure 1C-I). The gene discussed is IL1B; the disease is hepatocellular carcinoma.