In summary (Figure 8, graphical abstract), we reveal that SPTBN1 functions as a tumor suppressor to stabilize SOCS1 protein, controlling the cellular level of p65 to suppress the expression of inflammatory cytokines, IL-1α, IL-1β and IL-6, and the expansion of MDSCs and Foxp3+Treg cells. The gene discussed is SOCS1; the disease is neoplasm.