The Cox proportional hazards model showed that in the cohort of HCC patients with SPTBN1 low/IL-1β high, the ratio of SPTBN1 over IL-1β correlates with relapse free survival with a hazard ratio of 0.634 indicating the loss of SPTBN1 and/or increased level of IL-1β correlates with shorter relapse free survival (p = 0.03916). Here, SPTBN1 is linked to hepatocellular carcinoma.