The NF-κB activating protein (NKAP), a protein identified in our analysis to interact with unphosphorylated MARCKS, drew our attention owing to its role in directly activating NF-κB signaling, a smoke-related signaling pathway associated with cancer malignancy 10, 23, 24 (Figure 2A, right). The gene discussed is NFKB1; the disease is cancer.