In a screen of another cohort of lung cancer patients with smoking history (n = 151), downregulated expression of the inhibitory element of NF-κB signaling NFKBIA, which encodes the NF-κB inhibitory protein IκBα, was seen in lung cancer tissues from smokers and positively correlated with poor outcome (Figure S3B-C). The gene discussed is NFKB1; the disease is lung cancer.