To explore the effects of microglial miR-146a overexpression on metabolic pathways, especially on the neuroinflammation-related signalling pathways of AD, we analysed the transcriptional data of the cerebral samples of APP/PS1-AAV-M146a and APP/PS1-AAV-Mcon mouse group (Figure 7A). Here, PSEN1 is linked to Alzheimer disease.