AIF1 and Stroke: Stroke effect was observed in both groups (two-way RM ANOVA, p < 0.001): the percentage of Iba-1 positive area within the infarct was significantly increased compared to the contralateral striatum, for both control (p = 0.008) and HT-fed mice (p < 0.001) (Sidak's post hoc test) (Figure 8A).