Although impairment in oxidative metabolism is usually associated with increased glycolysis in cancer 67, we found that ADSL overexpression impairs glycolysis as well, thus suggesting that other metabolic pathways might fuel the energetic and anabolic demands of ADSL-overexpressing CRC cells, such as fatty acid metabolism that was also found significantly up-regulated upon ADSL overexpression. Here, ADSL is linked to colorectal carcinoma.