To further evaluate the clinical value of FOSL2-regulated Wnt5a involved in angiogenesis, we detected secreted Wnt5a levels in serum from 71 breast cancer patients and Wnt5a levels in corresponding tumor tissues or secreted Wnt5a in the supernatant of primary stromal fibroblasts isolated from 12 pairs of nontumor and tumor samples and the corresponding FOSL2 expression and vessel density of tumors. Here, FOSL2 is linked to breast cancer.