CDH5 and neoplasm: To confirm the number differences of blood vessels attributing to angiogenesis, the mRNA expressions of vascular endothelial (VE)-cadherin (CDH5), a strictly endothelial marker 35, and prosperohomeobox protein1 (prox1), a biomarker for lymphatic endothelial cells 36 were detected in the tumor samples (Figure S6B).